How Childhood Trauma & Toxic Stress Affect Health Across a Lifetime with Nadine Burke Harris

A special episode of Pathways from the New York State Trauma-Informed Network and Resource Center.

Posted on: December 9, 2025

On this special episode of Pathways from the New York State Trauma-Informed Network and Resource Center, Dr. Elizabeth Meeker welcomes Dr. Nadine Burke Harris for a rich discussion on Adverse Childhood Experiences (ACEs) and their profound impact on long-term health outcomes. As a medical doctor (pediatrician and first Surgeon General of California), Dr. Burke Harris shares her journey of understanding how childhood trauma affects biological development. 

Key topics of this episode include:

  • Expanding our understanding of adversity beyond the original 10 ACE categories
  • The groundbreaking ACEs study, published in 1998, and its findings about childhood adversity
  • How toxic stress affects – and changes – brain, immune, and hormonal systems
  • The relationship between childhood experiences and lifelong health risks like stroke and heart disease 
  • Methods for regulating and treating the toxic stress response

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